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Study: Fitness, Physical Activity Appear Superior to Weight Loss for Reducing Risks of Obesity

September 23, 2021


Obesity rates worldwide have tripled over the past four decades, resulting in a rise of a wide variety of health issues, including cardiovascular disease, diabetes, and cancer. In an attempt to address these health conditions, diets and weight loss efforts have also rapidly increased, many of those efforts bringing their own risks.

However, new research shows that when it comes to obese individuals getting healthy and reducing mortality risk, increasing physical activity and improving fitness appear to be superior to focusing only on losing weight. The study by Siddhartha Angadi, assistant professor of kinesiology in the UVA School of Education and Human Development, and Glenn Gaesser, professor of exercise physiology in the College of Health Solutions at Arizona State University, was published this month in the journal iScience.

“We would like people to know that fat can be fit, and that fit and healthy bodies come in all shapes and sizes,” Gaesser said. “We realize that in a weight-obsessed culture, it may be challenging for programs that are not focused on weight loss to gain traction. We’re not necessarily against weight loss; we just think that it shouldn’t be the primary criterion for judging the success of a lifestyle intervention program.”

Angadi said the point is “especially important when you consider the physiological realities of obesity.”

“Body weight is a highly heritable trait, and weight loss is associated with substantial metabolic alterations that ultimately thwart weight loss maintenance,” Angadi said.

In addition to risks associated with obesity, individuals also incur risks when weight cycling, commonly called “yo-yo” dieting, which is a repetitive pattern of weight loss and weight regain. Angadi and Gaesser said that employing a weight-neutral approach not only serves in the treatment of obesity-related health conditions, but it also reduces the health risks associated with that kind of dieting.

“Risks to weight cycling include muscle loss, fatty liver disease and diabetes,” Angadi said. “By focusing on fitness rather than weight loss, people can gain the benefits of exercise while avoiding the risks associated with weight cycling.”

Current public health guidelines recommend that adults accumulate 150-300 minutes per week of moderate-intensity physical activity or 75-150 minutes per week of vigorous-intensity physical activity.

“But it’s important to note that the benefits of exercise are dose-dependent, with the biggest benefits coming from just moving out of the couch-potato zone to doing at least some moderate-intensity activity,” Gaesser said. “It’s also important to emphasize that physical activity can be accumulated throughout the day. For example, multiple short walks during the day (even as short as two to 10 minutes each) are just as beneficial as one long walk for health benefits.”

In the study, Angadi and Gaesser cite recent research focused on the magnitude of mortality risk reduction associated with weight loss compared to that associated with an increase in physical activity or cardiorespiratory fitness. The risk reduction associated with increasing fitness and physical activity was consistently greater than that associated with intentional weight loss. They also looked at the magnitude of reduction in the risk markers of cardiovascular disease that are associated with either weight loss or increased physical activity. They reached these conclusions by examining research that analyzed pooled data across a multitude of studies (meta-analyses) that were carried out over a range of time periods and across broad geographical areas.

The researchers acknowledge limitations in the existing body of research, including the fact that this field is heavily reliant on epidemiological studies that do not definitively establish cause and effect, and note that only large, randomized, controlled clinical trials can fully examine the outcomes of using a fitness-focused approach to optimize cardiometabolic mortality risk in people who are obese.

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